骨干人才
姚永刚
姚永刚，1975年10月出生，博士，研究员。1997年毕业于安徽师范大学生物系，2003年于中国科学院昆明动物研究所获博士学位，2003年2月-2004年9月在约翰霍普金斯大学医学院从事博士后研究工作，2004年10月-2008年1月在美国国家健康研究院心脏、肺、血液研究所从事博士后研究工作。2007年12月回昆明动物研究所工作，担任疾病机理遗传学与进化医学团队负责人。2010年3月-2012年2月任昆明动物研究所所长助理，2012年3月-2014年7月任昆明动物研究所副所长（主持工作），2014年7月至今任昆明动物研究所所长。获得奖项及荣誉称号包括：国家自然科学奖二等奖（第二获奖人）、云南省有突出贡献优秀专业技术人才奖、朱李月华优秀教师奖等。2009年获得云南省高端科技人才计划和国家杰出青年基金资助，现主要承担中科院战略性科技专项（B类）（子课题负责人）和基金委重点与面上项目。
主要研究方向及内容
利用我国脑疾病样本资源和大规模组学分析手段，对阿尔茨海默病、精神分裂症等神经精神疾病的遗传易感性进行解析，从微观、介观、宏观3个层次深入开展细胞与动物实验，鉴定和脑疾病相关的致病基因与突变，揭示脑疾病的致病机理，建立致病基因突变、生物学标记、影像指标等的关联，用于指导临床早期诊断、遗传咨询、药物靶标发现与干预。
同时，致力于树鼩实验动物化和生物学研究及动物模型创建。
代表性论文
Luo R, Su L-Y, Li G, Yang J, Liu Q, Yang L-X, Zhang D-F, Zhou H, Xu M, Fan Y, Li J, Yao Y-G*. 2020. Activation of PPARA-mediated autophagy reduces Alzheimer’s disease-like pathology and cognitive decline in a murine model. Autophagy, 16: 52 - 69 (cover story).
Liu Q, Su L-Y*, Sun C, Jiao L, Miao Y, Xu M, Luo R, Zuo X, Zhou R, Zheng P, Xiong W, Xue T, Yao Y-G*. 2020. Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation. Redox Biology, 34: 101560 doi: 10.1016/j.redox.2020.101560.
Xu L, Yu D, Peng L, Wu Y, Fan Y, Gu T, Yao Y-L, Zhong J, Chen X, Yao Y-G*. 2020. An alternative splicing of Tupaia STING modulated anti-RNA virus responses by targeting MDA5-LGP2 and IRF3. The Journal of Immunology, doi: 10.4049/jimmunol.1901320.
Wu Y, Bi R, Zeng C, Ma C, Sun C, Li J, Xiao X, Li M, Zhang D-F, Zheng P, Sheng N*, Luo X-J*, Yao Y-G*. 2019. Identification of the primate-specific gene BTN3A2 as an additional schizophrenia risk gene in the MHC loci. EBioMedicine, 44: 530 - 541.
Zhang D-F, Fan Y, Xu M, Wang G, Wang D, Li J, Kong L-L, Zhou H, Luo R, Bi R, Wu Y, Li G-D, Alzheimer's Disease Neuroimaging Initiative, Li M, Luo X-J, Jiang H-Y, Tan L, Zhong C, Fang Y, Zhang C, Sheng N, Jiang T, Yao Y-G*. 2019. Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese. National Science Review, 6: 257 - 274.
Bi R*, Zhang W, Zhang D-F, Xu M, Fan Y, Hu Q-X, Jiang H-Y, Tan L, Li T, Fang Y, Zhang C, Yao Y-G*. 2018. Genetic association of the cytochrome c oxidase-related genes with Alzheimer's disease in Han Chinese. Neuropsychopharmacology, 43: 2264 - 2276.
Wang D, Fan Y, Malhi M, Bi R, Wu Y, Xu M, Yu X-F, Long H, Li Y-Y, Zhang D-F*, Yao Y-G*. 2018. Missense variants in HIF1A and LACC1 contribute to leprosy risk in Han Chinese. American Journal of Human Genetics, 102: 794 - 805
Xu M, Zhang D-F*, Luo R, Wu Y, Zhou H, Kong L-L, Bi R, Yao Y-G*. 2018. A systematic integrated analysis of brain expression profiles reveals YAP1 and other prioritized hub genes as important upstream regulators in Alzheimer's disease. Alzheimer's & Dementia, 14: 215 - 229.
Su L-Y, Luo R, Liu Q, Su J-R, Yang L-X, Ding Y-Q, Xu L*, Yao Y-G*. 2017. Atg5- and Atg7-dependent autophagy in dopaminergic neurons regulates cellular and behavioral responses to morphine. Autophagy, 13: 1496 - 1511 (cover story).
Yao Y-G*. 2017. Creating animal models, why not use the Chinese tree shrew (Tupaia belangeri chinensis)? Zoological Research, 38: 118 - 126 (cover story).
Tang J, Fan Y, Li H, Xiang Q, Zhang D-F, Li Z, He Y, Liao Y, Wang Y, He F, Zhang F, Shugart YY, Liu C, Tang Y*, Chan RCK*, Wang C-Y*, Yao Y-G*, Chen X*. 2017. Whole-genome sequencing of monozygotic twins discordant for schizophrenia indicates multiple genetic risk factors for schizophrenia. Journal of Genetics and Genomics, 44: 295-306.
Li G-D, Bi R, Zhang D-F, Xu M, Luo R, Wang D, Alzheimer's Disease Neuroimaging Initiative (ADNI), Fang Y, Li T, Zhang C, Yao Y-G*. 2017. Female-specific effect of the BDNF gene on Alzheimer's disease. Neurobiology of Aging, 53: 192.e11 - 192.e19.
Li C-H, Yan L-Z, Ban W-Z, Tu Q, Wu Y, Wang L, Bi R, Ji S, Ma Y-H, Nie W-H, Lv L-B, Yao Y-G*, Zhao X-D*, Zheng P*. 2017. Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring. Cell Research, 27: 241 - 252.
Wu Y, Yao Y-G*, Luo X-J*. 2017. SZDB: A database for schizophrenia genetic research. Schizophrenia Bulletin, 43: 459 - 471.
Xu L, Yu D, Fan Y, Peng L, Wu Y, Yao Y-G*. 2016. Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrew. Proceedings of the National Academy of Sciences of the United States of America, 113: 10950 - 10955
Zhang D-F, Li J, Wu H, Cui Y, Bi R, Zhou H-J, Wang H-Z, Zhang C, Wang D, Alzheimer's Disease Neuroimaging Initiative (ADNI), Kong Q-P, Li T, Fang Y, Jiang T*, Yao Y-G*. 2016. CFH variants affect structural and functional brain changes and genetic risk of Alzheimer's disease. Neuropsychopharmacology, 41: 1034 - 1045
Su LY, Li H, Lv L, Feng YM, Li GD, Luo R, Zhou HJ, Lei XG, Ma L, Li JL, Xu L, Hu XT*, Yao Y-G*. 2015. Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA/α-synuclein aggregation. Autophagy, 11: 1745 - 1759.
Bi R, Zhang W, Yu D, Li X, Wang H-Z, Hu Q-X, Zhang C, Lu W, Ni J, Fang Y, Li T, Yao Y-G*. 2015. Mitochondrial DNA haplogroup B5 confers genetic susceptibility to Alzheimer's disease in Han Chinese. Neurobiology of Aging, 36: 1604.e7 - 1604.e16.
Feng Y-M, Jia Y-F, Su L-Y, Wang D, Lv L, Xu L*, Yao Y-G*. 2013. Decreased mitochondrial DNA copy number in the hippocampus and peripheral blood during opiate addiction is mediated by autophagy and can be salvaged by melatonin. Autophagy, 9: 1395 - 1406.
Fan Y, Huang Z-Y, Cao C-C, Chen C-S, Chen Y-X, Fan D-D, He J, Hou H-L, Hu L, Hu X-T, Jiang X-T, Lai R, Lang Y-S, Liang B, Liao S-G, Mu D, Ma Y-Y, Niu Y-Y, Sun X-Q, Xia J-Q, Jin Xiao, Xiong Z-Q, Xu L, Yang L, Zhang Y, Zhao W, Zhao X-D, Zheng Y-T, Zhou J-M, Zhu Y-B, Zhang G-J*, Wang J*, Yao Y-G*. 2013. Genome of the Chinese tree shrew. Nature Communications, 4: 1426
Yao Y-G*, Kong Q-P, Salas A, Bandelt H-J. 2008. Pseudo-mitochondrial genome haunts disease studies. Journal of Medical Genetics, 45: 769 - 772.
Ji Y, Zhang A-M, Jia X, Zhang Y-P, Xiao X, Li S, Guo X, Bandelt H-J, Zhang Q, Yao Y-G*. 2008. Mitochondrial DNA haplogroups M7b1'2 and M8a affect clinical expression of Leber Hereditary Optic Neuropathy in Chinese families with the m.11778G>A mutation. American Journal of Human Genetics, 83: 760 - 768.