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顾 勇

顾勇,1974年12月生。现任中国科学院脑智卓越中心/神经科学研究所研究员,课题组组长,博士生导师。1997年毕业于厦门大学生物系,2002年于中国科学院生物物理研究所获博士学位,2002-2011年在美国圣路易斯华盛顿大学医学院从事博士后研究工作,2011年11月全职加入中科院神经科学研究所,担任空间感知机制课题组组长。

    主要研究方向及内容

    1、空间运动感知的神经基础  

    精确的空间感知需要整合多种感知觉信息,主要包括视觉光流和前庭信息。目前在大脑中已经发现多个脑区具有与空间运动感知相关的视觉光流和前庭信号,但是一个完整的神经环路还不清楚。我们以清新猕猴为实验动物,结合猕猴的行为学范式,应用在体电生理的技术记录猕猴大脑皮层神经元的电活动,并通过人为干扰皮层电活动的技术手段(微电流刺激、可逆性药物失活)来鉴定特定脑区与猕猴行为认知之间的因果关系。我们希望最终研究清楚视觉光流和前庭信号是如何在大脑中传输、加工和整合从而形成精确的空间感知觉输出及优化行为。

     

    2、多感觉信息整合与决策的机制  

    我们生活在一个多感知觉信息的世界中,每天我们的大脑都要处理来自不同渠道的相互独立、同时又冗余的信息。大量的心理物理学实验表明人类可以通过最优化整合理论(optimal cue integration theory)的方式整合多种感知觉信息来提高认知的精度,但是其神经机制还不清楚。我们通过在人和非人灵长类(猕猴)上的心理物理实验研究多种感知觉整合的方式。我们同时在做行为学范式的猕猴上记录大脑各个脑区神经元的电活动,包括各个多感觉脑区,以及后顶叶和前额叶与决策相关的脑区,研究单个和群体神经元是如何整合和累积各种感知觉信息,从而产生行为。我们的研究可以帮助加深理解人类的大脑在复杂多变的环境中,实时整合和累积感知觉信息证据的神经基础和计算原理,为类脑人工智能新型神经网络和智能体的开发提供启发和借鉴作用。

    代表性论文

    Hou, H., Zheng, Q., Zhao, Y., Pouget, A., & Gu, Y.* (2019) Neural Correlates of Optimal Multisensory Decision Making under Time-Varying Reliabilities with an Invariant Linear Probabilistic Population Code. Neuron 1041–12 

    Luo, J., He, K., Andolina,I., Li, X., Yin, J., Chen, Z., Gu, Y.,* & Wang, W.* (2019) Going with the flow: the neural mechanisms underlying illusions of complex-flow motion. J. Neurosci. 39: 2664-2685 

    Cheng, Z., & Gu, Y.* (2018) Vestibular system and self-motion. Front.Cell.Neurosci. : https://doi.org/10.3389/fncel.2018.00456 

    Zhang, Y., Yan, A., Liu, B., Wan, Y., Zhao, Y., Liu, Y., Tan, J., Song, L., Gu, Y.,* & Liu, Z.* (2018) Oculomotor performances are associated With motor and non-motor symptoms in Parkinson's Disease. Front. Neurol. : https://doi.org/10.3389/fneur.2018.00960 

    Yu, X., & Gu, Y.* (2018) Probing sensory readout via combined choice correlation measure and microstimulation perturbation. Neuron 100: 715-727 

    Gu, Y.* (2018) Vestibular signals in primate cortex for self-motion perception. Curr. Opin. Neurobiol. 52: 10-17 

    Yu, X., Hou, H., Spillmann, L., Gu, Y.* (2018) Causal evidence of motion signals in macaque middle temporal area weighted-pooled for global heading perception. Cereb. Cortex 28: 612-624 

    Yang, L., & Gu, Y.* (2017) Distinct spatial coordinate of visual and vestibular heading signals in macaque FEFsem and MSTd. ELife : doi: 10.7554/eLife.29809 

    Cheng, Z., & Gu, Y.* (2016) Distributed representation of curvilinear self-motion in macaque parietal cortex. Cell Reports 15: 1013-1023 

    Pan, Y., Wang, L., Wang, Z., Xu, C., Yu, W., Spillmann, L., Gu, Y.*, Wang, Z.*, Wang, W.* (2016) Representation of illusory and physical rotations in human MST: A cortical site for the pinna illusion. Hum. Brain Mapp. 37: 2097-113 

    Gu, Y.,* Cheng, Z., Yang, L., DeAngelis, G., Angelaki, D.* (2015) Multisensory convergence of visual and vestibular heading cues in the pursuit area of the frontal eye field. Cereb. Cortex 26: 3785-3801 

    Gu,Y., Angelaki, D., DeAngelis, G. (2014) Contribution of correlated noise and selective decoding to choice probability measurements in extrastriate visual cortex. ELife : doi: 10.7554/eLife.02670 

    Gu, Y., DeAngelis, G., Angelaki, D. (2012) Causal Links between Dorsal Medial Superior Temporal Area Neurons and Multisensory Heading Perception. J. Neurosci. 32: 2299-2313 

    Gu, Y.,, Liu, S., Fetsch, C., Yang, Y., Fok, S., Sunkara, A., DeAngelis, G., Angelaki, D. (2011) Perceptual learning reduces correlated noise in macaque extrastriate visual cortex. Neuron 71: 750-761 

    Gu, Y., Fetsch, C., Adeyemo, B., DeAngelis, G., Angelaki, D. (2010) Decoding of MSTd population activity accounts for variations in the precision of heading perception. Neuron 66: 596-609 

    Gu, Y., Angelaki, D., DeAngelis, G. (2008) Neural correlates of multi-sensory cue integration in macaque area MSTd. Nat. Neurosci. 11: 1201-10 

    Gu, Y., DeAngelis, G., Angelaki, D. (2007) A functional link between area MSTd and heading perception based on vestibular signals. Nat. Neurosci. 10: 1038-47 

    Gu, Y., Watkins, P., Angelaki, D., DeAngelis, G. (2006) Visual and nonvisual contributions to three-dimensional heading selectivity in the medial superior temporal area. J. Neurosci. 26: 73-85 

    实验室网址:http://www.cebsit.cas.cn/yjz/gy_/yjfx/ 

    E-mail: guyong@ion.ac.cn

    电话:021-54921745