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骨干人才

谌小维

谌小维，1980年4月生，博士，现任陆军军医大学基础医学院脑科学研究室研究员、主任。2004年毕业于第三军医大学临床医学专业，2008至2013年在德国慕尼黑工业大学获得博士学位并进行博士后研究。研究成果在Nature、Science、Nature Neuroscience、Neuron、PNAS等杂志发表论文50余篇，单篇最高引用超过400次，总引用率超过2400次，H因子21。获得科技部青年973项目（2015）、国家杰出青年基金（2020）、国家自然基金委中国-以色列科学基金合作项目等支持。主要从事大脑皮层信息处理机制研究，在树突整合、信息记忆、运动输出以及光学成像技术研发等方面取得成绩。

    主要研究方向及内容

    1、主要利用在体电生理、在体双光子显微功能成像以及光纤荧光探测/光遗传学等方法，从神经环路-细胞-突触多水平探索大脑皮层处理和记忆感觉信息的规律；

    2、发展双光子显微功能成像技术，同时建立神经计算相关方法。

    代表性论文

    Yang M, Zhou Z, Zhang J, Jia S, Li T, Guan J, Liao X, Leng B, Lyu J, Zhang K, Li Min, Gong Y, Zhu Z, Yan J, Zhou Y, Liu J, Varga Z, Konnerth A, Tang Y, Gao J, Chen X, Jia H. MATRIEX Imaging: Multiarea Two-photon Real-time In-vivo Explorer. (2019) Light Sci Appl 8:109.

    Ren S, Wang YL, Yue F, Cheng X, Dang R, Qiao Q, Sun X, Li X, Jiang Q, Yao J, Qin H, Wang G, Liao X, Gao D, Xia J, Zhang J, Hu B, Yan JA, Wang YJ, Xu M, Han Y, Tang X, Chen X*, He C*, Hu Z*. (2018) The paraventricular thalamus is a critical thalamic area for wakefulness. Science 362:429-434

    Yao J, Zhang Q, Liao X, Li Q, Liang S, Li X, Zhang Y, Li XN, Wang H, Qin H, Wang M, Li J, Zhang J, He W, Zhang W, Li T, Xu F, Gong H, Jia H, Xu X*, Yan J*, Chen X*. (2018) A corticopontine circuit for initiation of urination. Nature Neuroscience 21:1541-1550.

    Qin H, Fu L*, Hu B, Liao X, Lu J, He W, Liang S, Zhang K, Li R, Yao J, Yan J-A, Chen H, Jia H, Zott B, Konnerth A*, Chen X*. (2018) A visual cue-dependent memory circuit for place navigation. Neuron 99:47-55.

    Li R, Wang M, Yao J, Liang SS, Liao X, Yang M, Zhang J, Yan JA, Jia H, Chen X*, Li X*. (2018) Two-Photon Functional Imaging of the Auditory Cortex in Behaving Mice: From Neural Networks to Single Spines. Front Neural Circuits 24 April 2018.

    Guan J, Li J, Liang S, Li R, Li X, Shi X, Huang C, Zhang J, Pan J, Jia H, Zhang L, Chen X*, Liao X*. (2018) NeuroSeg: automated cell detection and segmentation for in vivo two-photon Ca2+ imaging data. Brain Struct Funct 223(1):519-533.

    Zhang K, Chen X*. (2017) Sensory response in host and engrafted astrocytes of adult brain in vivo. Glia 65:1867-1884. (Cover review paper)

    Ding R, Liao X, Li J, Zhang J, Wang M, Guang Y, Qin H, Li X, Zhang K, Liang S, Guan JH, Lou J, Jia H, Chen B*, Shen H*, Chen X*. (2017) Targeted Patching and Dendritic Ca2+ Imaging in Nonhuman Primate Brain in vivo. Sci Rep 7:2873.  

    Zhang QC, Yao JW, Guang Y, Liang SS, Guan JH, Qin H, Liao X, Jin WJ, Zhang JX, Pan JX, Jia HB, Yan JA, Feng ZZ*, Li WB*, Chen X*. (2017) Locomotion-related population cortical Ca2+ transients in freely behaving mice. Front Neural Circuits 11:24.

    Li J, Liao X*, Zhang J, Wang M, Yang N, Zhang J, Lv G, Li H, Lu J, Ding R, Li X, Guang Y, Yang Z, Qin H, Jin W, Zhang K, He C, Jia H, Zeng S, Hu Z, Nelken I, Chen X*. (2017) Primary auditory cortex is required for anticipatory motor response. Cereb Cortex 27:3254-3271.

    Zhang K, Chen C, Yang Z, He W, Liao X, Ma Q, Deng P, Lu J, Li J, Wang M, Li M, Zheng L, Zhou Z, Sun W, Wang L, Jia H, Yu Z, Zhou Z*, Chen X*. (2016) Sensory response of transplanted astrocytes in adult mammalian cortex in vivo. Cereb Cortex 26:3690-704. (Cover paper)

    Grienberger C, Chen X, Konnerth A. (2015) Dendritic function in vivo. Trends Neurosci 38:45-54.

    Grienberger C, Chen X, Konnerth A. (2014) NMDA receptor-dependent multidendrite calcium spikes required for hippocampal burst firing in vivo. Neuron 81:1274-81.

    Chen X*, Rochefort NL, Sakmann B, Konnerth A*. (2013) Reactivation of the same synapses during spontaneous up states and sensory stimuli. Cell Reports 4: 31-9.

    Busche MA, Chen X, Henning HA, Reichwald J, Staufenbiel M, Sakmann B, Konnerth A. (2012) Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 109:8740-5.

    Chen X#, Leischner U#, Varga Z, Jia H, Deca D, Rochefort NL, Konnerth A. (2012) LOTOS-based two-photon calcium imaging of dendritic spines in vivo. Nature Protoc 7:1818-29.

    Chen X#, Leischner U#, Rochefort NL, Nelken I, Konnerth A. (2011) Functional mapping of single spines in cortical neurons in vivo. Nature 475:501-5.

    Jia H, Rochefort NL, Chen X, Konnerth A*. (2011) In vivo two-photon imaging of sensory-evoked dendritic calcium signals in cortical neurons. Nat Protoc 6:28-35.

    Chen X#, Kovalchuk Y#, Adelsberger H, Henning HA, Sausbier M, Wietzorrek G, Ruth P, Yarom Y, Konnerth A. (2010) Disruption of the olivo-cerebellar circuit by Purkinje neuron-specific ablation of BK channels. Proc Natl Acad Sci USA 107: 12323-8. 

    Jia HB, Rochefort NL, Chen X, Konnerth A. (2010) Dendritic organization of sensory input to cortical neurons in vivo. Nature 464:1307-12.

    Chen X#, Feng YQ#, Hao CJ, Guo XL, He X, Zhou ZY, Guo N, Huang HP, Xiong W, Zheng H, Zuo PL, Zhang CX, Li W & Zhou Z. (2008) DTNBP1, a schizophrenia susceptibility gene, affects kinetics of transmitter release. J Cell Biol 181: 791-801.

    Chen X, Mu Y, Huang HP, Guo N, Zhang B, Fan SY, Xiong JX, Wang SR, Xiong W, Huang W, Liu T, Zheng LH, Zhang CX, Li LH, Yu ZP, Hu ZA & Zhou Z. (2008) Hypocretin-1 potentiates NMDA receptor-mediated somatodendritic secretion from locus ceruleus neurons. J Neurosci 28: 3202-3208.

    Huang HP, Wang SR, Yao W, Zhang C, Zhou Y, Chen X, Zhang B, Xiong W, Wang LY, Zheng LH, Landry M, Hokfelt T, Xu ZQ & Zhou Z. (2007) Long latency of evoked quantal transmitter release from somata of locus coeruleus neurons in rat pontine slices. Proc Natl Acad Sci USA 104: 1401-1406.

    E-mail: xiaowei_chen@tmmu.edu.cn

    电话：023-68771394