骨干人才
蔡时青
蔡时青，中科院上海植物生理生态研究所博士，美国新泽西州立（Rutgers）大学博士后。2009年回国担任中国科学院脑科学和智能技术卓越创新中心离子通道调控研究组组长。
主要研究方向及内容
研究方向主要包括： 1）健康衰老的分子生物学机制研究。早期研究发现一些长寿途径虽然可以延长寿命，但并不能延缓年老动物的神经递质减少和相应的行为退化（Yin et. al. Journal of Neuroscience，2014）。之后他们以神经递质系统在衰老中的变化为衰老的标记，通过分析个体之间衰老速度差异的遗传基础，发现了一条新的胶质细胞-神经元信号通路调控衰老速度（Yin et. al. Nature 2017）; 通过全基因组筛选发现新的抗衰老靶标基因，阐明了认知衰老的调控机制 (Yuan et. al. 2020)。2）离子通道功能调控机制研究。研究组利用线虫模式动物和哺乳动物细胞系，结合遗传学、生物化学、电生理等手段系统性地研究钾离子通道的表达和运输机制（Li et. al. Mol cell, 2017；Chen et. al. J neurosci, 2015；Bai et. al. J gen physiol, 2018)；通过构建线虫离子通道疾病动物模型，通过小分子化合物筛选寻找促进蛋白运输、上膜的化学物，致力于离子通道致病突变体的功能纠正及其机制研究（Jiang et. al. Nat Commun, 2018）。
代表性论文
Yuan, J., Chang, S., Yin,S., Liu, Z., Cheng, X., Liu, X., Jiang, Q., Gao, G., Lin, D., Kang, X., Ye, S., Chen, Z., Yin, J., Hao, P., Jiang, L.* & Cai, S.* (2020) Two conserved epigenetic regulators prevent healthy ageing. Nature 10: 1038.
Bai,X., Li,K., Yao,L., Kang,X., Cai, Shi-Qing.* (2018) A forward genetic screen identifies chaperone CNX-1 as a conserved biogenesis regulator of ERG K+ channels. J gen physiol 150: 1189-1201
Jiang,Q., Li,K., Lu,W., Li,S., Chen, X., Liu,X., Yuan,J., Ding, Q., Lan, F.,* , Cai, Shi-Qing,* (2018) Identification of small-molecule ion channel modulators in C. elegans channelopathy models. Nat commun 9: 3941
Jiang-An Yin#, Ge Gao#, Xi-Juan Liu, Zi-Qian Hao, Kai Li, Xin-Lei Kang, Hong Li, Yuan-Hong Shan, Wen-Li Hu, Hai-Peng Li & Shi-Qing Cai* (2017) Genetic variation in glia–neuron signalling modulates ageing rate. Nature 551:198–203
Kai Li#, Qiang Jiang#, Xue Bai, Yi-Feng Yang, Mei-Yu Ruan, Shi-Qing Cai* (2017)Tetrameric Assembly of K+ Channels Requires ER-Located Chaperone Proteins. Molecular Cell 65:52-65
Xin Chen, Mei-Yu Ruan, Shi-Qing Cai* (2015) Auxiliary subunits KChIPs of Kv4 channels regulate excitability of muscle cells and control male turning behavior during mating in Caenorhabditis elegans. The Journal of Neuroscience 35:1880-1891.
Jiang-An Yin, Xi-Juan Liu, Jie Yuan, Jing Jiang, and Shi-Qing Cai* (2014) Longevity manipulations differentially affect serotonin/dopamine level and behavioral deterioration in aging Caenorhabditis elegans. The Journal of Neuroscience 34: 3947-3958.
W. Tutak, Ki-Ho Park, G. Fanchini, A. Vasilov, Shi-Qing Cai, N. Partridge, F. Sesti* , M. Chhowalla* (2009). Toxicity induced enhanced extracellular matrix production in osteoblastic cells cultured on single walled carbon nanotube networks. Nanotechnology, 20 (25): 255101.
Shi-Qing Cai#, Wang Yi#, Ki Ho Park#, Xin Tong, Zui Pan and Federico Sesti* (2009) Auto-phosphorylation of a voltage-gated K + channel controls non-associative learning. EMBO J. 28 (11):1601-10.
Shi-Qing Cai and F. Sesti* (2009) Oxidation of a K+ Channel causes progressive decline in sensory function during ageing. Nature Neuroscience, 12 (5): 611-7.
L. Hernandez, K.H. Park, Shi-Qing Cai, L. Qin, N. Partridge, F. Sesti* (2007) The antiproliferative role of ERG K+ channels in rat osteoblastic cells. Cell Biochemstry Biophysics 47: 199-208.
Shi-Qing Cai and F. Sesti* (2007). A new mode of regulation of N-type inactivation in a Caenorhabditis elegans voltage-gated potassium channel. The Journal of Biological Chemistry 282(25): 18597-601.
Shi-Qing Cai, W. Li, F. Sesti* (2007) Multiple modes of A-type Potassium current regulation. Invited review. Current Pharmaceutical Design 13(31): 3178-84.
Shi-Qing Cai, Ki Ho Park, Federico Sesti* (2006) An evolutionarily conserved family of accessory subunits of K+ channels. Invited review. Cell Biochemstry Biophysics 46(1): 91-100.
Shi-Qing Cai, Leonardo Hernandez, Yi Wang, Ki Ho Park, Federico Sesti* (2005) MPS-1 is a K+ channel b-subunit and a serine/threonine kinase. Nature Neuroscience 8(11): 1503-9.
Ki Ho Park, Leonardo Hernandez, Shi-Qing Cai, Yi Wang, Federico Sesti* (2005) A family of K+ Channel ancillary subunits regulate taste sensitivity in Caenorhabditis elegans. The Journal of Biological Chemistry 280: 21893-21899.
Shi-Qing Cai, Gen-Yun Chen, Hai-Bo Zhang, Da-Quan Xu* (2002). No monomerisation of PSII dimer occurs during reversible inacivation of some photosystem II reaciton centers in soybean leavs. Photosynthetica 40 (2) 215-220.
Shi-Qing Cai, Da-Quan Xu* (2002). Light intensity-dependent reversible down-regulation and irreversible damage of photosystem II in soybean leaves. Plant Science Vol 163/4 pp 847-853.
Hai-Bo Zhang, Shi-Qing Cai, Da-Quan Xu* (2002). D1 protein phosphorylation/ dephosphorylation alone has no effect on the electron transport activity of photosystem II in soybean leaves. Plant Science 162, 507-511.
Yue Chen, Xue-Hua Wang, Yi Liao, Shi-Qing Cai, Hai-Bo Zhang, Da-Quan Xu* (2002) Effect of flag leaf orientation on its photosynthetic capacity in rice. Acta Phytophysiologia sinica 28 (5) 396-398.
Gen-Yun Chen, Yi Liao, Shi-Qing Cai, Qing Zeng, Jian-Guo Zhu, Yong Han, Gang Liu, Da-Quan Xu* (2002) Photosynthetic acclimation of Echinochloa crusgalli grown in rice field to free-air CO2 enrichment (FACE). Chinese Journal of Applied Ecology 13 (10): 1205-1209.
Yi Liao, Gen-Yun Chen, Shi-Qing Cai, Qing Zeng, Jian-Guo Zhu, Yong Han, Gang Liu, Da-Quan Xu* (2002) Responses and acclimation of photosynthesis to free-air carbon dioxide enrichment (FACE) in rice leaves. Chinese Journal of Applied Ecology 13(10): 1201-1204.
Shi-Qing Cai, Da-Quan Xu* (2000) Relationship between the CO2 compensation point and photorespiration in soybean leaves. Acta Phytophysiologia sinica, 26 (6): 545-550.