年轻骨干

穆 宇
穆宇,1984年出生于四川雅安,博士,研究员,中国科学院脑科学与智能技术卓越创新中心/神经科学研究所研究组长。2006年毕业于南京大学,生物化学系,获理学学士学位。2006年至2013年就读于中科院神经科学研究所,获理学博士学位。2013年至2020年在美国霍华德休斯医学研究所 (HHMI) 从事博士后研究工作。2020年4月加入中国科学院神经科学研究所,负责感觉-运动转导研究组。主要研究方向及内容
感觉-运动的形成常常来自多个脑区的同步协作。我们希望在全脑尺度完整理解脑的工作原理,即大脑如何处理感觉信息并启动行为,包括:(1)每个脑区各自将感觉信息进行加工的环路机制;(2)多个脑区实时地交互影响,整合、绑定生成的信息并最终形成行为输出的神经机制;(3)大脑局部和整体处理信息的基本原理。
代表性论文
Mu, Y.*#, Bennett, D. V. #, Rubinov, M. #, Narayan, S., Yang, C., Tanimoto, M., Mensh, B., Looger, L.L., and Ahrens, M.* (2019). Glia Accumulate Evidence that Actions Are Futile and Suppress Unsuccessful Behavior. Cell 178, 27-43.e19. ( * corresponding author, # co-first author, recommended by the F1000Prime)
Chen, X. #, Mu, Y. #, Hu, Y. #, Kuan, A. #, Nikitchenko, M., Randlett, O., Chen, A.B., Gavornik, J., Sompolinsky, H., Engert, F., and Ahrens, M. (2018). Brain-wide Organization of Neuronal Activity and Convergent Sensorimotor Transformations in Larval Zebrafish. Neuron 100, 876-890.e5. (# co-first author)
Vladimirov, N., Wang, C., H?ckendorf, B., Pujala, A., Tanimoto, M., Mu, Y., Yang, C., Wittenbach, J., Freeman, J., Preibisch, S., et al. (2018). Brain-wide circuit interrogation at the cellular level guided by online analysis of neuronal function. Nat. Methods 15, 1117–1125.
Dunn, T.#, Mu, Y. #, Narayan, S., Randlett, O., Naumann, E., Yang, C.T., Schier, A., Freeman, J., Engert, F., and Ahrens, M. (2016). Brain-wide mapping of neural activity controlling zebrafish exploratory locomotion. eLife 5. (# co-first author)
Pnevmatikakis, E., Soudry, D., Gao, Y., Machado, T.A., Merel, J., Pfau, D., Reardon, T., Mu, Y., Lacefield, C., Yang, W., et al. (2016). Simultaneous Denoising, Deconvolution, and Demixing of Calcium Imaging Data. Neuron 89, 285–299.
Vladimirov, N., Mu, Y., Kawashima, T., Bennett, D. V, Yang, C., Looger, L., Keller, P., Freeman, J., and Ahrens, M. (2014). Light-sheet functional imaging in fictively behaving zebrafish. Nat. Methods 883–884.
Freeman, J., Vladimirov, N., Kawashima, T., Mu, Y., Sofroniew, N., Bennett, D., Rosen, J., Yang, C., Looger, L., and Ahrens, M. (2014). Mapping brain activity at scale with cluster computing. Nat. Methods 11, 941–950.
Mu, Y. #, Li, X. #, Zhang, B., and Du, J. (2012). Visual Input Modulates Audiomotor Function via Hypothalamic Dopaminergic Neurons through a Cooperative Mechanism. Neuron 75, 688–699. (# co-first author)
实验室网址:http://www.cebsit.cas.cn/yjz/muyu/yjfx/
E-mail: my@ion.ac.cn
电话:021-54921827